A21 | Targeted Anti-Cancer Therapy (Emmy-Noether-Programme)

Research focus

The Reinhardt laboratory is focused on the analysis of signaling pathways that are activated in response to DNA damage. These signaling cascades serve to maintain genomic integrity and genes involved in the DNA damage response are among the most commonly mutated genes in human cancers. While these mutations clearly promote tumorigenesis they are also commonly associated with vulnerabilities that are specific to these genetic lesions. For example, cancer cells that have lost the prominent tumor suppressor p53 rely on genes such as ATM, Chk2 or MK2 to survive chemotherapy-induced DNA damage. We use mouse models and both human and mouse primary cells to characterize these genetic interactions, with the ultimate goal to develop tailored therapies that target the specific vulnerabilities of tumor cells.

Read more information on www.nf.mpg.de/onco-signaling/Research.html.

Principal Investigator

Christian Reinhardt

Prof. Dr. med. Christian Reinhardt

Cologne Center for Genomics
Weyertal 115b
50931 Köln
Phone +49-(0)221-478-96701
Fax     +49-(0)221-478-97835

Email:

Scientific career

1996 - 2003
Medical school, (Final grade: Sehr gut, highest honors), University of Hamburg, Germany; Humbold University, Berlin, Germany; University of Freiburg, Germany
1999 - 2003
MD thesis, Department of Internal Medicine, Division 4, University of Freiburg. Entitled: Expression of functional CC- and CXC chemokine receptors in podocytes. Advisor: Prof. Dr. H. Pavenstadt (Grade: Summa cum laude, highest honors)
2003
Postdoctoral Research Fellow University of Freiburg, Germany, Advisor: Profs. Dr. G. Walz and Dr. T. Benzing
2004
Postdoctoral Research Fellow, University of Münster, Germany, Advisor: Prof. Dr. H. Pavenstädt
2004 - 2009
Postdoctoral Associate, MIT, Department of Biology, Koch Institute, Advisors: Profs. M.B. Yaffe, MD, PhD and T. Jacks, PhD
2008
Habilitation for Molecular Medicine at the Medical Faculty of the University of Cologne
since 2009
Emmy-Noether Research group leader at the Medical Clinic I of the University Hospital Cologne

News

09 May 2012
CRC832 Seminar Series
Transcriptional networks regulating EMT and tumor progression (G. Christofori)
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14 - 16 May 2012
International Symposium of the Collaborative Research Center 832
Bad Neuenahr, Germany
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27 Feb 2012
Gunther Hartmann receives the Leibniz Prize 2012 together with Christian Kurts
press release »

Gender & Family Support
Flyer: women in science | work-life-balance »

Publications
aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation (Iden S et al.)
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