Research Projects

I. Scientific Projects

Project Title Research Area Principal Investigator,
Institute, Location
A1 Role of the novel Drosophila let-7 target gene wech in development and tumorigenesis Drosophila Genetics,
Molecular Cell Biology,
Growth Regulation
Michael Hoch,
LIMES
Universität Bonn
A2 Regulation of cell differentiation programming and cell-matrix interactions by TRIM71(Wech) in mammalian development and in tumors Molecular Cell Biology,
Tumor Biology
Waldemar Kolanus,
LIMES
Universität Bonn
A3 Intrinsic and extrinsic regulation of atypical protein kinase C (aPKC) mediated cell polarity and their role in skin cancer Dermatology, Molecular
Cell Biology, Epithelial
Cancer Biology
Carien Niessen,
Dermatologische Klinik,
ZMMK
Universität Köln
A4 A role for ciliary signaling in communication of cancer cells with the tumor microenvironment Molecular Cell Biology,
Molecular Medicine
Thomas Benzing
Bernhard Schermer,
Medizinische Klinik IV,
Universität Köln
A5 Regulation of signal transduction in lung cancer by the cytoskeleton and the tumor microenvironment Molecular Pathology,
Molecular Cell Biology,
Oncology
Reinhard Büttner
Lukas C. Heukamp,
Institut für Pathologie
Thomas M. Magin,
Institut für Biochemie und Molekularbiologie
Universität Bonn
A6 Validating the anti-angiogenic efficacy of anti-angiogenic compounds by a combined chemical genetics and imaging approach Cancer Genomics,
In vivo Molecular Imaging,
Clinical Trials
Roman Thomas
Roland Ullrich,
Max-Planck Institut für Neurologische Forschung Köln
Jürgen Wolf,
Klinik I für Innere Medizin
Universität Köln
A7 Effects of extracellular matrix proteins in the microenvironment on tumor progression Biochemistry,
Extracellular Matrix,
Cell – Matrix Interaction
Manuel Koch,
Institut für Biochemie II
Universität Köln
A9 The role of dysregulated mitochondrial apoptotic pathways as the basic prerequisite for the autonomic growth and metastatic progression of melanoma cells Molecular Cell Biology,
Apoptosis, Melanoma
Hamid Kashkar
Institut für Med.
Mikrobiol. Immunol. und Hygiene
Cornelia Mauch,
Klinik für Dermatologie
Universität Köln
A10 Highly effective antigen-specific elimination of tumors by CD8+ intraepithelial lymphocytes Tumor Immunology Olaf Utermöhlen,
Institut für Med. Mikrobiol. Immunol. und Hygiene
Universität Köln
A11 Molecular mechanisms leading to recruitment, accumulation and activation of regulatory T cells in the tumor microenvironment Tumor Immunology Marc Beyer
Joachim Schultze,
LIMES
Universität Bonn
A12 Regulation and modulation of anti-tumoral cytotoxic T cell responses in the microenvironment of primary and metastatic melanoma Experimental Dermatology,
Immunology,
Oncology
Thomas Tüting,
Dermatologische Klinik
Universität Bonn
A14 Modulation of tumor micromilieu and anti-tumour immunity by mast cells Tumor Immunology Karin Hartmann,
Klinik für Dermatologie
Universität Köln
A15 The role of inflammatory signals originating from the tumor microenvironment on the development and progression of hepatocellular carcinoma in vivo Genetics, Molecular Biology Thomas Wunderlich,
Institut für Genetik
Universität Köln
A16 Molecular modulation of leukemia-associated macrophages in the microenvironment of chronic lymphocytic leukemia (CLL) cells Hematology, Molecular Cell Biology Michael Hallek,
Klinik I für Innere Medizin
Universität Köln
A17 Role of TNF receptor 1 adaptor protein FAN in tumor migration and metastasis Tumor Immunology Martin Krönke,
Institut für Med. Mikrobiol. Immunol. und Hygiene
Universität Köln
A18 Genetic interactions between tumors and their microenvironment Genetics, Molecular cell biology,
Epithelial Cancer Biology
Mirka Uhlirova,
Institut für Genetik,
Universität Köln
A19 The role of extracellular NCR ligands for the cross-talk of NK cells and immune cells within the tumor microenvironment Tumor Immunology,
Immuno-Therapy
Elke Pogge von Strandmann,
Klinik I für Innere Medizin
Universität Köln
A20 Retinoic acid inducible protein I (RIG-I) in tumor biology Tumor Biology,
Immunology,
Nucleic Acids
Gunther Hartmann,
Institut für Klinische Chemie und Pharmakologie,
Universität Bonn
A21 Targeted Anti-Cancer Therapy (Emmy-Noether-Programme) Oncogene signaling,
DNA damage
Christian Reinhardt,
Klinik I für Innere Medizin,
Universität Köln

II. Central Projects

Project Title Research Area Principal Investigator,
Institute, Location
Z1 Histopathology platform for analysis of tumor microenvironment and immune cells Tumor Pathology,
Molecular Pathology
Reinhard Büttner
Eva Wardelmann,
Institut für Pathologie,
Bonn
Hans M. Kvasnicka,
Institut für Pathologie,
Köln
Z2 Molecular imaging of interactions between the tumor environment and tumor growth In-vivo Imaging of tumors (PET, BLI) Roland Ullrich
Bernd Neumaier,
Max-Planck Institut für Neurologische Forschung Köln
Z3 Core facility mouse   Jens Brüning,
Institut für Genetik,
Universität Köln
Thomas Tüting,
Dermatologische Klinik
Universität Bonn
Z4 Integrated Research Training Group   Elke Pogge von Strandmann,
Klinik I für Innere Medizin,
Universität zu Köln
Z5 Administration   Michael Hallek,
Klinik I für Innere Medizin,
Universität zu Köln

 

News

CRC832 Seminar Series
18 June 2014 | 5 pm (c.t.)
Changes in tissue and cellular organisation at early stages of colon cancer (Näthke I.)
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Publications
Transient anti-angiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer
(Chatterjee S. et al.)
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