| Project | Title | Research Area | Principal Investigator, Institute, Location |
|---|---|---|---|
| A1 | Role of the novel Drosophila let-7 target gene wech in development and tumorigenesis | Drosophila Genetics, Molecular Cell Biology, Growth Regulation |
Michael Hoch, LIMES Universität Bonn |
| A2 | Regulation of cell differentiation programming and cell-matrix interactions by TRIM71(Wech) in mammalian development and in tumors | Molecular Cell Biology, Tumor Biology |
Waldemar Kolanus, LIMES Universität Bonn |
| A3 | Intrinsic and extrinsic regulation of atypical protein kinase C (aPKC) mediated cell polarity and their role in skin cancer | Dermatology, Molecular Cell Biology, Epithelial Cancer Biology |
Carien Niessen, Dermatologische Klinik, ZMMK Universität Köln |
| A4 | A role for ciliary signaling in communication of cancer cells with the tumor microenvironment | Molecular Cell Biology, Molecular Medicine |
Thomas Benzing Bernhard Schermer, Medizinische Klinik IV, Universität Köln |
| A5 | Regulation of signal transduction in lung cancer by the cytoskeleton and the tumor microenvironment | Molecular Pathology, Molecular Cell Biology, Oncology |
Reinhard Büttner Lukas C. Heukamp, Institut für Pathologie Thomas M. Magin, Institut für Biochemie und Molekularbiologie Universität Bonn |
| A6 | Validating the anti-angiogenic efficacy of anti-angiogenic compounds by a combined chemical genetics and imaging approach | Cancer Genomics, In vivo Molecular Imaging, Clinical Trials |
Roman Thomas Roland Ullrich, Max-Planck Institut für Neurologische Forschung Köln Jürgen Wolf, Klinik I für Innere Medizin Universität Köln |
| A7 | Effects of extracellular matrix proteins in the microenvironment on tumor progression | Biochemistry, Extracellular Matrix, Cell – Matrix Interaction |
Manuel Koch, Institut für Biochemie II Universität Köln |
| A9 | The role of dysregulated mitochondrial apoptotic pathways as the basic prerequisite for the autonomic growth and metastatic progression of melanoma cells | Molecular Cell Biology, Apoptosis, Melanoma |
Hamid Kashkar Institut für Med. Mikrobiol. Immunol. und Hygiene Cornelia Mauch, Klinik für Dermatologie Universität Köln |
| A10 | Highly effective antigen-specific elimination of tumors by CD8+ intraepithelial lymphocytes | Tumor Immunology | Olaf Utermöhlen, Institut für Med. Mikrobiol. Immunol. und Hygiene Universität Köln |
| A11 | Molecular mechanisms leading to recruitment, accumulation and activation of regulatory T cells in the tumor microenvironment | Tumor Immunology | Marc Beyer Joachim Schultze, LIMES Universität Bonn |
| A12 | Regulation and modulation of anti-tumoral cytotoxic T cell responses in the microenvironment of primary and metastatic melanoma | Experimental
Dermatology, Immunology, Oncology |
Thomas Tüting, Dermatologische Klinik Universität Bonn |
| A14 | Modulation of tumor micromilieu and anti-tumour immunity by mast cells | Tumor Immunology | Karin Hartmann, Klinik für Dermatologie Universität Köln |
| A15 | The role of inflammatory signals originating from the tumor microenvironment on the development and progression of hepatocellular carcinoma in vivo | Genetics, Molecular Biology | Thomas Wunderlich, Institut für Genetik Universität Köln |
| A16 | Molecular modulation of leukemia-associated macrophages in the microenvironment of chronic lymphocytic leukemia (CLL) cells | Hematology, Molecular Cell Biology | Michael Hallek, Klinik I für Innere Medizin Universität Köln |
| A17 | Role of TNF receptor 1 adaptor protein FAN in tumor migration and metastasis | Tumor Immunology | Martin Krönke, Institut für Med. Mikrobiol. Immunol. und Hygiene Universität Köln |
| A18 | Genetic interactions between tumors and their microenvironment | Genetics, Molecular cell
biology, Epithelial Cancer Biology |
Mirka Uhlirova, Institut für Genetik, Universität Köln |
| A19 | The role of extracellular NCR ligands for the cross-talk of NK cells and immune cells within the tumor microenvironment | Tumor Immunology, Immuno-Therapy |
Elke Pogge von
Strandmann, Klinik I für Innere Medizin Universität Köln |
| A20 | Retinoic acid inducible protein I (RIG-I) in tumor biology | Tumor Biology, Immunology, Nucleic Acids |
Gunther Hartmann, Institut für Klinische Chemie und Pharmakologie, Universität Bonn |
| A21 | Targeted Anti-Cancer Therapy (Emmy-Noether-Programme) | Oncogene signaling, DNA damage |
Christian Reinhardt, Klinik I für Innere Medizin, Universität Köln |
| Project | Title | Research Area | Principal Investigator, Institute, Location |
|---|---|---|---|
| Z1 | Histopathology platform for analysis of tumor microenvironment and immune cells | Tumor Pathology, Molecular Pathology |
Reinhard Büttner Eva Wardelmann, Institut für Pathologie, Bonn Hans M. Kvasnicka, Institut für Pathologie, Köln |
| Z2 | Molecular imaging of interactions between the tumor environment and tumor growth | In-vivo Imaging of tumors (PET, BLI) | Roland Ullrich Bernd Neumaier, Max-Planck Institut für Neurologische Forschung Köln |
| Z3 | Core facility mouse | Jens Brüning, Institut für Genetik, Universität Köln Thomas Tüting, Dermatologische Klinik Universität Bonn |
|
| Z4 | Integrated Research Training Group | Elke Pogge von Strandmann, Klinik I für Innere Medizin, Universität zu Köln |
|
| Z5 | Administration | Michael Hallek, Klinik I für Innere Medizin, Universität zu Köln |
Part of the scientific programme of
25 Jan 2012
CRC832 Seminar Series
Linking adaptive and innate immunity in the liver (Prof. Dr. Percy Knolle)
more»
CRC832 Retreat 2011
Impressions »
Gender & Family Support
Flyer: women in science | work-life-balance »
14 - 16 May 2012
International Symposium of the Collaborative Research Center 832
Bad Neuenahr, Germany
Preliminary programme »
27 Feb 2012
Gunther Hartmann receives the Leibniz Prize 2012 together with Christian Kurts
press release »
Publications
Genetic insight and therapeutic targets in squamous-cell lung cancer (Sos ML and Thomas RK)
more »
The Collaborative Research Centre 832 is funded by 